background patients with intellectual disabilities may be treated with antipsychotic medications for a variety of diagnoses. use of this category of medication can increase prolactin levels and place the patient at risk for sexual dysfunction and lower bone mineral density. the proposed mechanism of action is affinity for the dopamine receptor. use of bromocriptine, a dopamine receptor antagoni...

treatment of tuberculosis was an obstacle for ages. in spite of good drugs, the disease is not under control. thus, the need for more drugs existed. searching for a new drug demands much investment on the time, money and human resources. there are many drugs with antitubercular action that are discovered and explored in the last century. the most common drug, isoniazid, is now a frontrunner ant...

objective: sexual dysfunction in patients who take antipsychotics causes adecline in their quality of life and medication acceptance. considering the restrictions in cross sectional design of many earlier researches, we used a clinical trial aimed at assessing sexual dysfunction by substituting risperidone, an atypical antipsychotic drug, with haloperidol, a typical one . method: this clinical ...

traditionally, schizophrenia was considered to be a severe psychiatric disorder, with a chronic course and an unfavorable outcome. throughout history, there has been incidence of schizophrenia, roughly one percent of the population, consistently, in every culture. it is generally acknowledged that schizophrenia has multifactorial etiology, with multiple susceptibility genes interacting with env...

objective: the lithium concentration in the plasma is assumed to give someindication as to the concentration of this ion in different organ cells especially incentral nervous system. while the practical value of intracellular lithium measurement is controversial however, erythrocytes have proved to be useful for studying lithium concentration and its transport across the membrane. there are som...

objective: the present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, sdas) and depot preparation of conventional (typical) antipsychotics. methods: in this historical cohort study, mean relapse per month (mrm) index, duration between initiation of antipsychotic treatment and the first relapse epis...

OBJECTIVES Anecdotal evidence suggests that second-generation antipsychotic agents are increasingly used to treat sleep problems. This study sought to quantify the proportion of new prescriptions for second-generation antipsychotic agents started for sleep/sedation and the correlates of such use. DESIGN A cross-sectional survey of provider decision making at the time second-generation antipsy...

AIM Patient populations that are prescribed antipsychotic agents have higher cardiovascular mortality rates. The risk of myocardial infarction is influenced by various factors that are more prevalent in patients with a mental illness. The aim of this review was to determine whether the use of antipsychotic agents is associated with the incidence of myocardial infarction in adults. METHODS Usi...